Rucaparib (AG014699) is an orally active and potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay. Rucaparib shows binding affinity to eight other PARP domains.

Product information

CAS Number: 283173-50-2

Molecular Weight: 323.36

Formula: C19H18FN3O

Synonym:

AG-14699

AG014447 (as free base)

PF-01367338

Rucaparib free base

Rubraca

Related CAS Number:

459868-92-9 (Rucaparib phosphate)

1859053-21-6 (Rucaparib Camsylate)

Chemical Name: 6-fluoro-2-{4-[(methylamino)methyl]phenyl}-3, 10-diazatricyclo[6.4.1.0, ]trideca-1, 4, 6, 8(13)-tetraen-9-one

Smiles: CNCC1C=CC(=CC=1)C1NC2=CC(F)=CC3C(=O)NCCC=1C=32

InChiKey: HMABYWSNWIZPAG-UHFFFAOYSA-N

InChi: InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

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