α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM.

Product information

CAS Number: 216299-21-7

Molecular Weight: 1572.76

Formula: C65H89N17O21S4

Chemical Name: 2-[53-[(2-aminoacetyl)amino]-18-(2-amino-2-oxoethyl)-27-benzyl-6-carbamoyl-21-(1-hydroxyethyl)-48-(hydroxymethyl)-45-[(4-hydroxyphenyl)methyl]-24-methyl-8, 11, 17, 20, 23, 26, 29, 32, 38, 44, 47, 50, 52-tridecaoxo-3, 4, 55, 56-tetrathia-7, 10, 16, 19, 22, 25, 28, 31, 37, 43, 46, 49, 51-tridecazapentacyclo[28.20.7.012, 16.033, 37.039, 43]heptapentacontan-9-yl]acetic acid

Smiles: CC(O)C1NC(=O)C(C)NC(=O)C(CC2C=CC=CC=2)NC(=O)C2CSSCC(NC(=O)CN)C(=O)NC(CSSCC(NC(=O)C(CC(O)=O)NC(=O)C3CCCN3C(=O)C(CC(N)=O)NC1=O)C(N)=O)C(=O)NC(CO)C(=O)NC(CC1C=CC(O)=CC=1)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N2

InChiKey: SVNSCQIKKAACJG-UHFFFAOYSA-N

InChi: InChI=1S/C65H89N17O21S4/c1-31-53(91)79-51(32(2)84)62(100)74-39(23-48(67)86)64(102)80-18-6-11-45(80)60(98)72-37(24-50(88)89)55(93)76-41(52(68)90)27-104-106-29-43-59(97)75-40(26-83)56(94)73-38(22-34-14-16-35(85)17-15-34)63(101)82-20-8-13-47(82)65(103)81-19-7-12-46(81)61(99)78-44(30-107-105-28-42(57(95)77-43)70-49(87)25-66)58(96)71-36(54(92)69-31)21-33-9-4-3-5-10-33/h3-5,9-10,14-17,31-32,36-47,51,83-85H,6-8,11-13,18-30,66H2,1-2H3,(H2,67,86)(H2,68,90)(H,69,92)(H,70,87)(H,71,96)(H,72,98)(H,73,94)(H,74,100)(H,75,97)(H,76,93)(H,77,95)(H,78,99)(H,79,91)(H,88,89)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

α-Conotoxin AuIB blocks the α3β4 receptor with >100-fold higher potency than other receptor subunit combinations, including α2β2, α2β4, α3β2, α4β2, α4β4, and α1β1γδ.

References:

1. Siqin Luo, et al. α-Conotoxin AuIB Selectively Blocks α3β4 Nicotinic Acetylcholine Receptors and Nicotine-Evoked Norepinephrine Release.Journal of Neuroscience. 1998 Nov 1, 18 (21): 8571-8579.

Products are for research use only. Not for human use.