PROTAC CRABP-II Degrader-3 is a potent cellular retinoic acid binding protein (CRABP-II) degrader based on cIAp1.

Product information

CAS Number: 1225383-41-4

Molecular Weight: 853.05

Formula: C46H68N4O11

Chemical Name: (2E, 4E, 6E, 8E)-9-((E)-3-((17S, 20S, 21R)-21-amino-20-hydroxy-17-isobutyl-2, 16, 19-trioxo-22-phenyl-6, 9, 12, 15-tetraoxa-3, 18-diazadocosyloxyimino)-2, 6, 6-trimethylcyclohex-1-enyl)-3, 7-dimethylnona-2, 4, 6, 8-tetraenoic acid

Smiles: CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)CC1=CC=CC=C1)C(=O)OCCOCCOCCOCCNC(=O)CO/N=C1\CCC(C)(C)C(C=C/C(/C)=C/C=C/C(/C)=C/C(O)=O)=C\1C |t:47|

InChiKey: RZIQIEBBFSSCIQ-KMRDRQGYSA-N

InChi: InChI=1S/C46H68N4O11/c1-32(2)28-40(49-44(55)43(54)38(47)30-36-14-9-8-10-15-36)45(56)60-27-26-59-25-24-58-23-22-57-21-20-48-41(51)31-61-50-39-18-19-46(6,7)37(35(39)5)17-16-33(3)12-11-13-34(4)29-42(52)53/h8-17,29,32,38,40,43,54H,18-28,30-31,47H2,1-7H3,(H,48,51)(H,49,55)(H,52,53)/b13-11+,17-16+,33-12+,34-29+,50-39+/t38-,40+,43+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.

Products are for research use only. Not for human use.