E2F-1 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES8529-50, ES8529-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media

Alternate Name: E2F1 RBBP3

Source: Rabbit

Applications: IF; WB; IHC; ELISA

Dilution: IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

Reactivity: Human; Mouse; Rat

Immunogen: Synthetic peptide from human protein at AA range: 100-170

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 1869

Human SWISS Prot NO: Q01094

Subcellular Location: Nucleus

Research Use Only