Csk (phospho Ser364) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4854-50, ES4854-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases., PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., subcellular location:Mainly cytoplasmic, also present in lipid rafts., subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1., tissue specificity:Expressed in lung and macrophages.,

Alternate Name: CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Csk around the phosphorylation site of Ser364. AA range:330-379

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 55kD

Human Gene ID: 1445

Human SWISS Prot NO: P41240

Subcellular Location: Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.

Research Use Only