DYR1A Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA32094-50, RA32094-100 Citations, Manuals and MSDS Available upon request. Background: dual specificity tyrosine phosphorylation regulated kinase 1A (DYRK1A) Homo sapiens This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' co Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000 Applications: WB; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 1859 Protein MW (KDa): 83 SWISS: Q13627 Source: Rabbit Research Use Only