CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM). CP-601927 shows good brain penetration and antidepressant-like properties.

Product information

CAS Number: 357425-02-6

Molecular Weight: 227.23

Formula: C12H12F3N

Chemical Name: (1S,8R)-4-(trifluoromethyl)-10-azatricyclo[6.3.1.0²,⁷]dodeca-2(7),3,5-triene

Smiles: FC(F)(F)C1=CC2[C@@H]3C[C@@H](CNC3)C=2C=C1

InChiKey: RNOBTWYQAWEZHH-JGVFFNPUSA-N

InChi: InChI=1S/C12H12F3N/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9/h1-2,4,7-8,16H,3,5-6H2/t7-,8+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

CP-601927 (0.125 mg/kg-1.5 mg/kg; i.p.; C57BL/6J male mice) has antidepressant-like activity in animal models.

Products are for research use only. Not for human use.