Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new drug development.

Product information

CAS Number: 76001-09-7

Molecular Weight: 357.40

Formula: C19H23N3O4

Chemical Name: 3-[({[2-(3,4-dimethoxyphenyl)ethyl]carbamoyl}methyl)amino]benzamide

Smiles: COC1=CC=C(CCNC(=O)CNC2=CC(=CC=C2)C(N)=O)C=C1OC

InChiKey: KZOFCELNVLSKGC-UHFFFAOYSA-N

InChi: InChI=1S/C19H23N3O4/c1-25-16-7-6-13(10-17(16)26-2)8-9-21-18(23)12-22-15-5-3-4-14(11-15)19(20)24/h3-7,10-11,22H,8-9,12H2,1-2H3,(H2,20,24)(H,21,23)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

The hydrochloride form shows incompatibility with the excipients used for oral dosage forms. There are several crystal forms of the free base, namely, alpha-anhydrate, beta-anhydrate, monohydrate, and trihydrate. The trihydrate form is unstable. The degree of crystallinity of the beta-anhydrate form is difficult to control. The monohydrate form is difficult to manufacture with constant quality. The serum levels of the compounds in rats are almost related to the dissolution rates in the JP 1st disintegration medium from the discs. The serum level of alpha-anhydrate is the lowest.

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